Research interests

  • Method development for molecular dynamics simulations
  • Ion channels
  • Intramembrane proteolysis
  • Structure-based drug design
  • Protein-ligand interactions
  • NMR spectroscopy of organic molecules
  • Stereochemistry

Research Units in UniSysCat

Awards (selection)

2018 Stipend of the Christiane Nüsslein-Volhard Foundation
2012 Award for Outstanding Chinese Students Abroad

Prof. Dr. Han Sun
Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP)
Robert-Rössle-Str. 10
13125 Berlin
+49 30 94793 573

Publications (selection)

M. Schewe, E. Nematian-Ardestani, H. Sun, M. Musinszki, S. Cordeiro, G. Bucci, B. Groot, S. J. Tucker, M. Rapedius, T. Baukrowitz, A Non-canonical Voltage-Sensing Mechanism Controls Gating in K2P K+ Channels, Cell 2016, 164, 937-949.

C. Shi, Y. He, K. Hendriks, B. L. de Groot, X. Cai, C. Tian, A. Lange, H. Sun, A Single NaK Channel Conformation is not Enough for Non-selective Ion Conduction, Nature Communications 2018, 9, 717.

H. Sun, U. M. Reinscheid, E. L. Whitson, E. J. d’Auvergne, C. M. Ireland, A. Navarro-Vázquez,  C. Griesinger, Challenge of Large-Scale Motion for Residual Dipolar Coupling Based Analysis of Configuration: The Case of Fibrosterol Sulfate A, Journal of the American Chemical Society 2011, 133, 14629-14636.

H. Sun, A. Horatscheck, V. Martos, M. Bartetzko, U. Uhrig, D. Lentz, P. Schmieder, M. Nazaré, Direct Experimental Evidence for Halogen-Aryl π Interactions in Solution from Molecular Torsion Balances, Angewandte Chemie International Edition 2017, 56, 6454-6458.

K. Wolkenstein, H. Sun, H. Falk, C. Griesinger, Structure and Absolute Configuration of Jurassic Polyketide-Derived Spiroborate Pigments Obtained from Microgram Quantities, Journal of the American Chemical Society  2015, 137, 13460-13463.

H. Sun, E. J. d’Auvergne, U. M. Reinscheid, L. C. Dias, C. K. Z. Andrade, R. Oliveira Rocha, C. Griesinger,  Bijvoet in Solution Reveals Unexpected Stereoselectivity in a Michael Addition. Chemistry - A European Journal 2011, 17, 1811-1817.

H. M. Ge, H. Sun, N. Jiang, Y. H. Qin, H. Dou, T. Yan, Y. Y. Hou, C. Griesinger, R. X. Tan, Relative and Absolute Configuration of Vatiparol (1 mg): A Novel Anti-inflammatory Polyphenol, Chemistry - A European Journal 2012, 18, 5213-5221.

W. Zong, G. W. Li, J. M. Cao, X. Lei, M. L. Hu, H. Sun, C. Griesinger, R. X. Tan, An Alignment Medium for Measuring Residual Dipolar Couplings in Pure DMSO: Liquid Crystals from Graphene Oxide Grafted with Polymer Brushes. Angewandte Chemie International Edition 2016, 55, 3690-3693.

M. Schmidt, H. Sun, P. Rogne, G. K. E. Scriba, C. Griesinger, L. T. Kuhn, U. M. Reinscheid, Determining the Absolute Configuration of (+)-Mefloquine HCl, the Side-Effect-Reducing Enantiomer of the Antimalaria Drug Lariam, Journal of the American Chemical Society 2012, 134, 3080–3083.

X. Lei, Z. Xu, H. Sun, S. Wang, C. Griesinger, L. Peng, C. Gao, R. X. Tan, Graphene Oxide Liquid Crystals as a Versatile and Tunable Alignment Medium for the Measurement of Residual Dipolar Couplings in Organic Solvents. Journal of the American Chemical Society 2014, 136, 11280-11283.

Latest News

Rhomboid proteases are promising targets for drug development. Researchers from the Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) and UniSysCat have published new findings about them in Science Advances.

Neuroscientists are looking for accurate sensors to image nerve signals in tissue, particularly the brain. UniSysCat researchers now shed light on the voltage-sensing mechanism of the fluorescence of microbial rhodopsins.