Research interests

  • chemical biology approaches to elucidate second messenger signaling
  • development of inositol pyrophosphate analogs to study their structure and function
  • chemical biology tools for the annotation of the pyrophosphoproteome
  • linking signaling and metabolism via implementing novel analytical strategies

Research Units in UniSysCat

Awards (selection)

2013 National Institutes of Health (NIH) Director’s New Innovator Award, USA
2013 Rita Allen Scholar Award, Princeton NJ, USA
2013 Kimmel Scholar Award, Baltimore MD, USA
2009 National Institutes of Health (NIH) Pathway to Independence Award, USA
2007 Fastrack Program, Robert Bosch Foundation
2007 Ernst Schering Foundation Postdoctoral Fellowship

Prof. Dr. Dorothea Fiedler 
Leibniz-Institut für Molekulare Pharmakologie (FMP) Berlin
Chemical Biology
Robert-Rössle-Straße 10
13125 Berlin
+49 (0)30 94793 151

Publications (selection)

M. Penkert, L. M. Yates, M. Schümann, D. Perlman, D. Fiedler, E. Krause E, Unambiguous identification of serine and threonine pyrophosphorylation using neutral-loss-triggered electron-transfer/higher-energy collision dissociation, Analytical Chemistry 2017, 89, 3672–3680.

M. Wu, L. S. Chong, D. H. Perlman, A. C. Resnick, D. Fiedler, The inositol polyphosphates intersect with protein signaling and metabolic networks via two distinct mechanisms, Proceedings of the National Academy of Sciences of the United States of America 2016, 113, E6757–E6765.

A. Hager, M. Wu, H. Wang, N. W. Brown Jr., S. B. Shears, N. Veiga, D. Fiedler, Cellular cations control conformational switching of inositol pyrophosphate analogues, Chemistry – A European Journal 2016, 22, 12406–12414.

L. M. Yates, D. Fiedler, A stable pyrophosphoserine analog for incorporation into peptides and proteins, ACS Chemical Biology 2016, 11, 1066–1073.

F. J. Williams, D. Fiedler, A fluorescent sensor and gel stain for detection of pyrophosphorylated proteins, ACS Chemical Biology 2015, 10, 1958–1963.

J. H. Conway, D. Fiedler, An affinity reagent for recognition of pyrophosphorylated peptides, Angewandte Chemie International Edition 2015, 54, 3941–3945.

M. Wu, L. S. Chong, S. Capolicchio, H. J. Jessen, A. C. Resnick, D. Fiedler, Elucidating diphosphoinositol polyphosphate function with nonhydrolyzable analogues, Angewandte Chemie International Edition 2014, 53, 7192–7197.

A. M. Marmelstein, L. M. Yates, J. H. Conway, D. Fiedler, Chemical pyrophosphorylation of functionally diverse peptides, Journal of the American Chemical Society 2014, 136, 108–111.

M. Wu, B. E. Dul, A. J. Trevisan, D. Fiedler, Synthesis and characterization of nonhydrolyzable diphosphoinositol polyphosphate messengers, Chemical Science 2013, 4, 405–410.

D. Fiedler, H. Braberg, M. Mehta, G. Chechik, G. Cagney, P. Mukherjee, A. C. Silva, M. Shales, S. R. Collins S. van Wageningen, P. Kemmeren, F. C. P. Holstege, J. S. Weissman, M. Christopher-Keogh, D. Koller, K. M. Shokat, N. J. Krogan, Functional organization of the S. cerevisiae phosphorylation network, Cell 2009, 136, 952–963.