Research interests

  • structure, dynamics, and function of biomolecules (redox enzymes, photoreceptors)
  • electron transfer
  • interfacial processes of immobilised proteins
  • electric field effects
  • vibrational spectroscopy, (resonance)  Raman,  IR,  SE(R)R,  SEIRA,  spectroelectrochemistry,  spectra  calculations

Research Units in UniSysCat

Awards (selection)

2003– Visiting Professor, ITQB, UN Lisboa (Portugal)
1998 Visiting Professor, Universidad Nacional de La Plata (Argentina)
1993 Heisenberg Fellowship of German Research Foundation (DFG)
1990 Bennigsen-Foerder Award
1989 ADUC Award of the German Chemical Society
1985 Otto-Hahn Medal of the Max Planck Society

Prof. Dr. Peter Hildebrandt 
TU Berlin
Institute of Chemistry, Office PC 14
Straße des 17. Juni 135
10623 Berlin
+49 (0)30 314-21419
+49 (0)30 314-21122

Publications (selection)

T. Werther, S. Wahlefeld, J. Salewski, U. Kuhlmann, I. Zebger, P. Hildebrandt, H. Dobbek, Redox-dependent substrate-cofactor interactions in the Michaelis-complex of a flavin-dependent oxidoreductase, Nature Communications 2017, 8, 16084.

A. Schmidt, L. Sauthof, M. Szczepek, M. Fernandez Lopez, F. Velazquez Escobar, B.M. Qureshi, N. Michael, D. Buhrke, T. Stevens, D. Kwiatkowski, D. von Stetten, M.A. Mroginski, N. Krauß, T.  Lamparter, P. Hildebrandt, P. Scheerer, Structural snapshot of a bacterial phytochrome in its functional intermediate state. Nature Communications 2018, 9, 4012.

H. Biava, T. Schreiber, S. Katz, J.S. Völler, M. Stolarski, C. Schulz, N. Michael, N. Budisa, M. Kozuch, T. Utesch, P. Hildebrandt, Long-Range Modulations of Electric Fields in Proteins. J. Phys. Chem. B. 2018, 122, 8330–8342.

A. Ciaccafava, D. Tombolelli, L. Dominik, J. Fesseler, J.-H. Jeoung, H. Dobbek, M. A. Mroginski, I. Zebger, P. Hildebrandt, When the inhibitor tells more than the substrate: the cyanide-bound state of a carbon monoxide dehydrogenase, Chemical Science 2016, 7, 3162–3171.

F. Velazquez Escobar, P. Piwowarski, J. Salewski, N. Michael, M. Fernandez Lopez, A. Rupp, B. M. Qureshi, P. Scheerer, F. Bartl, N. Frankenberg-Dinkel, F. Siebert, M. A. Mroginski, P. Hildebrandt, A protonation-coupled feedback mechanism controls the signaling process in bathy phytochromes, Nature Chemistry 2015, 7, 423–430.

X. X. Han, L. Chen, U. Kuhlmann, C. Schulz, I. M. Weidinger, P. Hildebrandt, Magnetic titanium dioxide nanocomposites for surface-enhanced resonance raman spectroscopic determination and degradation of toxic anilines and phenols, Angewandte Chemie International Edition 2014, 53, 2481–2484.

J. Salewski, F. Velazquez Escobar, S. Kaminski, D. von Stetten, A. Keidel, Y. Rippers, N. Michael, P. Scheerer, P. Piwowarski, F. Bartl, N. Frankenberg-Dinkel, S. Ringsdorf, W. Gärtner, T. Lamparter, M. A. Mroginski, P. Hildebrandt, The structure of the biliverdin cofactor in the Pfr state of bathy and prototypical phytochromes, The Journal Of Biological Chemistry 2013, 288, 16800–16814.

E. Siebert, M. Horch, Y. Rippers, J. Fritsch, S. Frielingsdorf, O. Lenz, F. Velazquez Escobar, F. Siebert, L. Paasche, U. Kuhlmann, F. Lendzian, M. A. Mroginski, I. Zebger, P. Hildebrandt, Resonance Raman spectroscopy as a novel tool to monitor the active site of hydrogenases: new insights into structure and reactivity, Angewandte Chemie International Edition 2013, 52, 5162–5165.

J. Kozuch, C. Steinem, D. Millo, P. Hildebrandt, Combined electrochemistry and surface-enhanced infrared absorption spectroscopy of gramicidin A incorporated into tethered bilayer lipid membranes, Angewandte Chemie International Edition 2012, 51, 8114–8117.

G. Schkolnik, T. Utesch, K. Tenger, D. Millo, A. Kranich, I. Zebger, C. Schulz, L. Zimányi, G. Rákhely, M. A. Mroginski, P. Hildebrandt, Mapping local electric fields in proteins at biomimetic interfaces, Chemical Communications 2012, 48, 70–72.

M. Sezer, D. Millo, I. Weidinger, I. Zebger, P. Hildebrandt, Analysing the catalytic processes of immobilised redox enzymes by vibrational spectroscopies, IUBMB Life 2012, 64, 455–464.

Latest News

Two joint works of 3 Unisyscat groups show the vital role of sulfur: non-innocence in the catalytic reduction of dioxygen to hydrogen peroxide & in mimicking the reactivity of ribonucleotide reductases

Four UniSysCat groups deciphered the multistep incorporation process of the catalytic NiFe(CN)2(CO) cofactor into [NiFe]-hydrogenase, paving the way for chemical reconstitution of this biocatalyst.

Neuroscientists are looking for accurate sensors to image nerve signals in tissue, particularly the brain. UniSysCat researchers now shed light on the voltage-sensing mechanism of the fluorescence of microbial rhodopsins.