Research interests

  • Functional networks of proteins by co-regulation
  • Functional networks of proteins by crosslinking mass spectrometry
  • Technology development around mass spectrometric data

Research Units in UniSysCat

Awards (selection)

2021 EMBO membership
2017 Visiting professor, Kyoto University, Japan (JSPS long term fellow)
2014-2019 Senior Research Fellow of the Wellcome Trust
2014 BSPR lectureship 2014
2011 Einstein Professorship
2009-2014 Senior Research Fellow of the Wellcome Trust
2005-2010 Marie Curie Excellence Fellow
2001-2003 Marie Curie Fellow

Prof. Dr. Juri Rappsilber
TU Berlin
Institute of Biotechnology, Office TIB 4/4-3
Gustav-Meyer-Allee 25
13355 Berlin
+49 30 314-72374

Publications (selection)

G. Kustatscher, P. Grabowski, J. Rappsilber, Pervasive coexpression of spatially proximal genes is buffered at the protein level, Molecular Systems Biology 2017, 13, 937.

A. Belsom, M. Schneider, L. Fischer, O. Brock* & J. Rappsilber*, Serum Albumin Domain Structures in Human Blood Serum by Mass Spectrometry and Computational Biology, Molecular & Cellular Proteomics 2016, 15, 1105–1116.

R.J. Jr. Tomko , D.W. Taylor, Z.A. Chen, H-W. Wang, J. Rappsilber*, M. Hochstrasser*, A Single α Helix Drives Extensive Remodeling of the Proteasome Lid and Completion of Regulatory Particle Assembly, Cell  2015, 163, 432–444.

C.W. Combe, L. Fischer, J. Rappsilber,  xiNET: cross-link network maps with residue resolution, Molecular & Cellular Proteomics 2015, 14, 1137–1147.

G. Kustatscher, K.L.H. Wills, C. Furlan, J. Rappsilber, Chromatin enrichment for proteomics, Nature Protocols 2014, 9, 2090–2099.

C. Alabert, J-C. Bukowski-Wills, S-B. Lee, G. Kustatscher, K. Nakamura, F. de Lima Alves, P. Menard, J. Mejlvang, J. Rappsilber*, A. Growth*,  Nascent chromatin capture proteomics determines chromatin dynamics during DNA replication and identifies unknown fork components, Nature Cell Biology 2014, 16, 281–293.

G. Kustatscher, N. Hégarat, K.L.H. Wills, C. Furlan, J-C. Bukowski-Wills, H. Hochegger*, J. Rappsilber*,  Proteomics of a fuzzy organelle: interphase chromatin, The EMBO Journal 2014, 33, 648–664.

S. Ohta , J-C. Bukowski-Wills, L. Sanchez-Pulido, F. de L. Alves, L. Wood, Z.A. Chen, M. Platani, L. Fischer, D.F. Hudson, C.P. Ponting, T. Fukagawa, W.C. Earnshaw*, J. Rappsilber*, The protein composition of mitotic chromosomes determined using multiclassifier combinatorial proteomics, Cell 2010, 142, 810–821.

Z.A. Chen, A. Jawhari, L. Fischer, C. Buchen, S. Tahir, T. Kamenski, M. Rasmussen, L. Lariviere, J-C. Bukowski-Wills, M. Nilges, P. Cramer, J. Rappsilber,  Architecture of the RNA polymerase II-TFIIF complex revealed by cross-linking and mass spectrometry, The EMBO Journal 2010, 29, 717–726.

J. Rappsilber, Y. Ishihama, M. Mann, Stop and go extraction tips for matrix-assisted laser desorption/ionization, nanoelectrospray, and LC/MS sample pretreatment in proteomics, Analytical Chemistry 2003, 75, 663–670.

* shared communicating/senior authors

Latest News

Bold and visionary ideas that challenge the limits of what can be imagined– read our interview with UniSysCat group leader Juri Rappsilber about the innovative "TransFORM" project.

Scientists of UniSysCat and SCIoI combined experimental data and deep learning (AI) for a new structure prediction level of challenging targets