Research interests

  • solid-state NMR method development
  • biophysical and chemical applications
  • membrane protein structure, dynamics, and function
  • intramembrane proteolysis
  • selective and non-selective cation channels
  • supramolecular protein assemblies

Research Units in UniSysCat

Awards (selection)

2016 Founders’ Medal of the International Council on Magnetic Resonance in Biological Systems (ICMRBS)
2013 ERC Starting Grant
2009 Emmy Noether stipend
2007 EMBO long-term fellowship
2006 Otto Hahn Medal of the Max Planck Society
2006 Ernst Award of the German Chemical Society

Prof. Dr. Adam Lange
Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP)
Robert-Rössle-Str. 10
13125 Berlin
+ 49 (30)94793190
+ 49 (30)94793199

Publications (selection)

A. Lange, K. Giller, S. Hornig, M. F. Martin-Eauclaire, O. Pongs, S. Becker, and M. Baldus, Toxin-induced conformational changes in a potassium channel revealed by solid-state NMR, Nature 2006, 440, 959-962.

C. Wasmer, A. Lange, H. Van Melckebeke, A. B. Siemer, R. Riek, and B. H. Meier, Amyloid fibrils of the HET-s(218-289) prion form a beta solenoid with a triangular hydrophobic core, Science 2008, 319, 1523-1526.

A. Loquet, N. G. Sgourakis, R. Gupta, K. Giller, D. Riedel, C. Goosmann, C. Griesinger, M. Kolbe, D. Baker, S. Becker, and A. Lange, Atomic model of the type III secretion system needle, Nature 2012, 486, 276-279.

V. Daebel, S. Chinnathambi, J. Biernat, M. Schwalbe, B. Habenstein, A. Loquet, E. Akoury, K. Tepper, H. Müller, M. Baldus, C. Griesinger, M. Zweckstetter, E. Mandelkow, V. Vijayan, and A. Lange, b-sheet core of tau paired helical filaments revealed by solid-state NMR, Journal of the American Chemical Society 2012, 134, 13982-13989.

J.-P. Demers, B. Habenstein, A. Loquet, S. K. Vasa, K. Giller, S. Becker, D. Baker, A. Lange*, and N. G. Sgourakis*, High-resolution structure of the Shigella type-III secretion needle determined by solid-state NMR and cryo-electron microscopy, Nature Communications 2014, 5, 4976.     

S. Vasa, L. Lin, C. Shi, B. Habenstein, D. Riedel, J. Kühn, M. Thanbichler, and A. Lange, β-Helical architecture of cytoskeletal bactofilin filaments revealed by solid-state NMR, Proceedings of the National Academy of Sciences 2015, 112, E127-E136.

C. Shi, P. Fricke, L. Lin, V. Chevelkov, M. Wegstroth, K. Giller, S. Becker, M. Thanbichler, and A. Lange, Atomic-resolution structure of cytoskeletal bactofilin by solid-state NMR, Science Advances 2015, 1, e1501087.    

P. Fricke, V. Chevelkov, M. Zinke, K. Giller, S. Becker, and A. Lange, Backbone assignment of perdeuterated proteins by solid-state NMR using proton-detection and ultrafast magic-angle spinning, Nature Protocols, 2017, 12, 764-782.       

M. Zinke, P. Fricke, C. Samson, S. Hwang, J. S. Wall, S. Lange, S. Zinn-Justin, and A. Lange, Bacteriophage tail tube assembly studied by proton-detected 4D solid-state NMR, Angewandte Chemie – International Edition 2017, 56, 9497-9501.     

C. Shi, Y. He, K. Hendriks, B. L. de Groot, X. Cai, C. Tian, A. Lange, H. Sun, A single NaK channel conformation is not enough for non-selective ion conduction, Nature Communications 2018, 9, 717.

Latest News

Rhomboid proteases are promising targets for drug development. Researchers from the Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) and UniSysCat have published new findings about them in Science Advances.