Prof. Dr. Roderich D. Süssmuth

Research interests

  • structure and mechanisms RiPP biosynthesis complexes
  • bioactivity and molecular targets of RiPPs
  • biotechnological generation of RiPPs

Research Units in UniSysCat

Awards (selection)

2014 Appointment “Van Arkel Chair 2014”, Universiteit Leiden, the Netherlands
2013 Visiting professorship, Ben-Gurion-University Beer-Sheva, Israel
2010 Sigma-Aldrich Lecture, Lunteren, the Netherlands
2006 Lecture Award (Dozentenstipendium) of the German Chemical Industry Fund (VCI
2003 Lilly Lecture Award by Eli-Lilly, Germany
2003 Junior Scientist Award for Natural Product Research of DECHEMA
2002 Friedrich-Weygand-Award of the Max Bergmann Kreis
2002 Emmy Noether Fellowship of the DFG
2000 Feodor Lynen Fellowship of the Alexander von Humboldt Foundation

Prof. Dr. Roderich D. Süssmuth
Technische Universität Berlin
Institut für Chemie / C141 / Sekr. C3
Straße des 17. Juni 115
10623 Berlin
+49 (0)3031424205
+49 (0)3031479651
suessmuth(at)chem.tu-berlin.de
www.biochemie.tu-berlin.de

Publications (selection)

L. Rostock, R. Driller, S. Grätz, D. Kerwat, L. von Eckardstein, D. Petras, M. Kunert, C. Alings, F.-J. Schmitt, T. Friedrich, MC. Wahl, B. Loll, A. Mainz, R. D. Süssmuth, Molecular insights into antibiotic resistance - how a binding protein traps albicidin, Nature Communication 2018, 9, 3095.

V. Wiebach, A. Mainz, M.-A. J. Siegert, G. Lesquame, S. Tirat, A. Dreux-Zigha, J. Aszodi, D. Le Beller; R. D. Süssmuth, The anti-staphylococcal lipolanthines are ribosomally synthesized lipopeptides, Nature Chemical Biology 2018, 14, 652–654.

C. Steiniger, S. Hoffmann, A. Mainz, M. Kaiser, K. Voigt, V. Meyer, R. D. Süssmuth, Harnessing fungal nonribosomal cyclodepsipeptide synthetases for mechanistic insights and tailored engineering, Chemical Science 2017, 8, 7834-7843.

S. Ramm, B. Krawczyk, A. Mühlenweg, A. Poch, E. Mösker, RD. Süssmuth, A self-sacrificing N-methyltransferase is the precursor of the fungal natural product omphalotin, Angewandte Chemie International Edition 2017, 56, 9994-9997.

S. Cociancich, A. Pesic, D. Petras, S. Uhlmann, J. Kretz, V. Schubert, L. Vieweg, S. Duplan, M. Marguerettaz, J. Noëll, I. Pieretti, M. Hügelland, S. Kemper, A. Mainz, P. Rott, M. Royer, R. D. Süssmuth, The gyrase inhibitor albicidin consists of para-aminobenzoic acids and cyanoalanine, Nature Chemical Biology 2015, 11, 195-197.

J. Kretz, D. Kerwat, V. Schubert, S. Grätz, A. Pesic, S. Semsary, S. Cociancich, M. Royer, RD. Süssmuth, Total synthesis of albicidin - a new class of potent antibacterial gyrase inhibitors from Xanthomonas albilineans, Angewandte Chemie International Edition 2015, 54, 1969-1973.

N. Jungmann, B. Krawczyk, M. Tietzmann, P. Ensle, RD. Süssmuth, Dissecting reactions of non-linear precursor peptide processing of the class III lanthipeptide curvopeptin, Journal of the American Chemical Society 2014, 136, 15222-15228.

K. Haslinger, C. Brieke, S. Uhlmann, L. Sieverling, M. Cryle, RD. Süssmuth, The structure of a transient complex of a nonribosomal peptide synthetase and a cytochrome-P450 monooxygenase, Angewandte Chemie International Edition 2014, 53, 8518-8522.

S. Müller, E. Garcia-Gonzalez, A. Mainz, G. Hertlein, N. Heid, E. Mösker, H. van den Elst, H. Overkleeft, E. Genersch, R. D. Süssmuth, Paenilamicin – structure and biosynthesis of a hybrid non-ribosomal peptide/polyketide antibiotic from the bee pathogen Paenibacillus larvae, Angewandte Chemie International Edition 2014, 53, 10821-10825.

G. Völler, B. Krawczyk, P. Ensle, RD. Süssmuth, Involvement and unusual substrate specifity of a prolyl oligopeptidase in class III lanthipeptide maturation, Journal of the American Chemical Society 2013, 135, 7426-7429.

Patents

“Separation material comprising phosphoryl choline derivatives”V.Prisyazhnoy, A. Sheriff, S. Mattecka, RD. Süssmuth, PCT/EP2015/063887, July 2016

"Method for obtaining microbial secondary metabolites of derivatives thereof by heterologous expression of at least one synthetase of said secondary metabolites in filamentous fungi." S. Boecker, D. Storm, V. Meyer, L. Richter, S, Zobel, F. Wanka, RD. Süssmuth, A. Mühlenweg: PCT/EP 2015/055978, March 2015.

"Albicidin derivatives, their use and synthesis" J. Kretz, V. Schubert, A. Pesic, M. Hügelland, M. Royer, S. Cociancich, D. Kerwat, S. Grätz, RD. Süssmuth: PCT/EP2014/052922, August 2014.

"Method for recombinant production of labyrinthopeptins and functional derivatives thereof." J. Wink, S. Brönstrup, L. Toti, RD. Süssmuth, J. Krawczyk: PCT/EP2012/076099 September 2013.