Prof. Dr. Peter Hegemann

Research interests

  • molecular photobiology: blue-light receptors, unusual rhodopsins
  • biochemistry
  • algal biotechnology
  • optogentics

Research Units in UniSysCat

Awards (selection)

2018 Otto Warburg Medaille der GBM (German Society for Biochemistry and Mol. Biology)
2017 Leopoldina Mendel Medaille, Halle
2017 Harvey Prize, Technion, Haifa (Israel)
2016 Massry Prize, Meira and Shaul G. Massry Foundation, Los Angeles (USA)
2016 Honorary Bonhoeffer Prize Lecture, Göttingen
2016 European Research Council (ERC) Advanced Grant on: Mechanism of Enzyme Rhodopsin Activation (MERA)
2016 Hector Science Award and Hector Fellow, Heidelberg
2015 Mayors Science Prize of Berlin
2014 Member of the Academy of Science and Engineering (acatech)
2014 Member of the Berlin-Brandenburg Academy of Sciences and Humanities
2014 Member of the European Molecular Biology Organization EMBO
2013 Brain Prize of the G. Lundbeck European Brain Research Prize Foundation, Copenhagen (Denmark)
2013 Louis-Jeantet Award, Geneva (Switzerland)
2013 Leibniz Prize of the German Research Foundation (DFG)
2013 Member of the German National Academy of Sciences, Leopoldina

Prof. Dr. Peter Hegemann 
HU Berlin
Department of Biology
Invalidenstraße 42
10115 Berlin
+49 (0)30 2093-8681
hegemann(at)rz.hu-berlin.de
www.biologie.hu-berlin.de/hegemann-peter

UniSysCat Publications

  • Design of a light-gated proton channel based on the crystal structure of Coccomyxa rhodopsin, R. Fudim, M. Szczepek, J. Vierock, A. Vogt, A. Schmidt, G. Kleinau, P. Fischer, F. Bartl, P. Scheerer, P. Hegemann, Science Signaling 2019, 12, 10.1126/scisignal.aav4203

Publications (selection)

K. Deisseroth, P. Hegemann, The form and function of channelrhodopsin, Science 2017, 357, 6356.

D. Petroutsos, R. Tokutsu, S. Maruyama, S. Flori, A. Greiner, L. Magneschi, L. Cusant, T. Kottke, M. Mittag, P. Hegemann, G. Finazzi, J. Minagawa, A blue light photoreceptor mediates the feedback regulation of photosynthesis, Nature 2016, 537, 563–566.

N. Takahashi, T. Oertner, P. Hegemann, M. E. Larkum, Perceptual detection depends on a dendritic mechanism in cortical pyramidal cells, Science 2016, 354, 1587–1590.

E. A. Ferenczi, J. Vierock, K. Atsuta-Tsunoda, S. P. Tsunoda, C. Ramakrishnan, C. Gorini, K. Thompson, S. Y. Lee, A. Berndt, C. Perry, S. Minniberger, A. Vogt, J. Mattis, R. Prakash, S. Delp, K. Deisseroth, P. Hegemann, Optogenetic approaches addressing extracellular modulation of neural excitability, Scientific Reports 2016, 6, 23947.

D. Petroutsos, R. Tokutsu, S. Maruyama, S. Flori, A. Greiner, L. Magneschi, L. Cusant, T. Kottke, M. Mittag, P. Hegemann, G. Finazzi, J. Minagawa, A blue light photoreceptor mediates the feedback regulation of photosynthesis, Nature 2016, 537, 563–566.

B. R. Rost, F. Schneider, M. K. Grauel, C. Wozny, C.G. Bentz, A. Blessing, T. Rosenmund, T. J. Jentsch, D. Schmitz, P. Hegemann, C. Rosenmund, Optogenetic acidification of synaptic vesicles and lysosomes, Nature Neuroscience 2015, 18, 1845–1852.

U. Scheib, K. Stehfest, C. E. Gee, H. G. Korschen, R. Fudim, T. G. Oertner, P. Hegemann, The rhodopsin-guanylyl cyclase of the aquatic fungus Blastocladiella emersonii enables fast optical control of cGMP signaling, Science Signaling 2015, 8, rs8.

J. Wietek, J. S. Wiegert, N. Adeishvili, F. Schneider, H. Watanabe, S. P. Tsunoda, A. Vogt, M. Elstner, T. G. Oertner, P. Hegemann, Conversion of channelrhodopsin into a light-gated chloride channel, Science 2015, 344, 409–412.

O. Yizhar, L. E. Fenno, M. Prigge, F. Schneider, T. J. Davidson, D. J. O’Shea, V. S. Sohal, I. Goshen, J. Finkelstein, J. T. Paz, K. Stehfest, R. Fudim, C. Ramakrishnan, J. R. Huguenard, P. Hegemann, K. Deisseroth, Neocortical excitation/inhibition balance in information processing and social dysfunction, Nature 2011, 477, 171–178.

F. Zhang, J. Vierock, O. Yizhar, L. E. Fenno, S. Tsunoda, A. Kianianmomeni, M. Prigge, A. Berndt, Cushman, J. Polle, J. Magnuson, P. Hegemann, K. Deisseroth, The microbial opsin family of optogenetic tools, Cell 2011, 147, 1446–1457.

Patents

K. Deisseroth, O. Yizhar, L. Gunaydin, P. Hegemann, A. Berndt, Optically-based stimulation of target cells and modifications thereto, 2009, US20110311489 A1, US9309296 B2, WO/2010/056970.

K. Deisseroth, L. Fenno, P. Hegemann, M. Prigge, O. Yizhar, Light-activated chimeric opsins and methods of using the same, 2012, WO2012061676, PCT/US2011/059276, US9175095, US 15/147,772.

K. Deisseroth, E. Ferencczi, P. Hegemann, System for modulating the membrane potential of a cell, comprises nucleotide sequences encoding a light-activated protein and a response protein that responds to the passage of the ion through the cell membrane, 2014, WO2014179331A2.

K. Deisseroth, O. Yizhar, L. Fenno, P. Hegemann, M. Prigge, New Animal cell e.g. muscle cell comprising light-activated protein expressed on cell membrane, where protein is e.g. chimeric protein (Volvox channelrhodopsin-1) from Volvox carteri used for e.g. selectively depolarizing excitatory neurons, 2011, WO2012066179-A2, AU2011323226-A1, CA2816971-A1, WO2012061679-A3, EP2635108-A2, JP2014500716-W, CN103492564-A.