Prof. Dr. Joachim Heberle

Research interests

  • time-resolved, surface-enhanced and near-field vibrational spectroscopy
  • photosensory and photosynthetic processes
  • membrane proteins
  • signal transduction
  • bioelectrochemistry
  • molecular biophysics
  • ion and electron transfer
  • surface structuring and functionalisation

Research Units in UniSysCat

Prof. Dr. Joachim Heberle
FU Berlin
Department of Physics
Arnimallee 14
14195 Berlin
+49 (0)30 838-56161
+49 (0)30 838-453337

Publications (selection)

J. O. Daldrop, M. Saita, M. Heyden, V. A. Lórenz-Fonfría, J. Heberle, Netz, R.R. Orientation of non-spherical protonated water clusters revealed by infrared absorption dichroism, Nature Communications 2018, 9 , Art. No 311, Doi 10.1038/s41467-017-02669-9.

V. A. Lórenz-Fonfría, M. Saita, T. Lazarova, T., Schlesinger, R., J. Heberle, pH-sensitive vibrational probe reveals a cytoplasmic protonated cluster in bacteriorhodopsin, Proceedings of the National Academy of Sciences of the United States of America 2017, 114, E10909–E10918.

T. Kottke, V. A. Lórenz-Fonfría, J. Heberle, The grateful infrared – sequential protein structural changes resolved by IR difference spectroscopy, The Journal of Physical Chemistry B 2017, 121, 335–350.

O. Berntsson, R. P. Diensthuber, M. R. Panman, A. Björling, E. Gustavsson, M. Hoernke, A. J. Hughes, L. Henry, S. Niebling, H. Takala, J. A. Ihalainen, G. Newby, S. Kerruth, J. Heberle, M. Liebi, A. Menzel, R. Henning, I. Kosheleva, A. Möglich, S. Westenhoff, Sequential conformational transitions and α -helical supercoiling regulate a sensor histidine kinase, Nature Communications 2017, 8, 284.

M. Senger, S. Mebs, J. Duanc, F. Wittkamp, U.-P. Apfel, J. Heberle, M. Haumann, S. T. Stripp, Stepwise isotope editing of [FeFe]-hydrogenases exposes cofactor dynamics, Proceedings of the National Academy of Sciences of the United States of America 2016, 113, 8454–8459.

C. Schnedermann, V. Muders,  D. Ehrenberg,  R. Schlesinger,  P. Kukura,  J. Heberle, Vibronic Dynamics of the ultrafast all-trans to 13-cis photoisomerization of retinal in channelrhodopsin-1, Journal of the American Chemical Society 2016, 138, 4757–4762.

V. A. Lórenz-Fonfría, B. J. Schultz, T. Resler, R. Schlesinger, C. Bamann, E. Bamberg, J. Heberle, Pre-gating conformational changes in the ChETA variant of channelrhodopsin-2 monitored by nanosecond IR spectroscopy, Journal of the American Chemical Society 2015, 137, 1850–1861.

I. Amenabar, S. Poly, W. Nuansing, E. H. Hubrich, A. Govyadinov, F. Huth, R. Krutokhvostov, L. Zhang, M. Knez, J. Heberle, A. Bittner, R. Hillenbrand, Structural analysis and mapping of individual protein complexes by infrared nanospectroscopy, Nature Communications 2013, 4, 2890.

V. A. Lórenz-Fonfría, T. Resler, N. Krause, M. Nack, M. Gossing, G. Fischer von Mollard, C. Bamann, E. Bamberg, R. Schlesinger, J. Heberle, Transient protonation changes in channelrhodopsin-2 and their relevance to channel gating, Proceedings of the National Academy of Sciences of the United States of America 2013, 110, E1273–1281.

J. Heberle, J. Riesle, G. Thiedemann, D. Oesterhelt, N. A. Dencher, Proton migration along the membrane surface and retarded surface to bulk transfer, Nature 1994, 370, 379–382.


B. Süss, J. Heberle, Oscillating reflector with ultrasonic resonator, interferometer with an oscillating reflector and Fourier transform spectrometer, 2014, EP14194520.4.